Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes
نویسندگان
چکیده
منابع مشابه
Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes.
BACKGROUND Characterization of the immunoglobulin gene repertoire has improved our understanding of the immunopathogenesis of lymphoid tumors. Early B-lymphocyte precursors of multiple myeloma are known to exist and might be susceptible to antigenic drive. DESIGN AND METHODS To verify this hypothesis, we collected a database of 345 fully readable multiple myeloma immunoglobulin sequences. We ...
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The frequency of expression of immunoglobulin (Ig) light and heavy chain isotypes was analyzed in myeloma proteins (M-proteins) from sera of 40 Indian patients with clinically established multiple myeloma. Patients samples were screened by a combination of electrophoresis, immunoelectrophoresis (IEP) and ELISA techniques in this study. We found that majority of the myeloma proteins (58%) were o...
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BACKGROUND The use of electrophoresis to monitor monoclonal immunoglobulins migrating in the β fraction may be difficult because of their comigration with transferrin and complement proteins. METHODS Immunoassays specific for IgGκ, IgGλ, IgAκ, IgAλ, IgMκ, and IgMλ heavy/light chain (HLC) were validated for use in the clinical laboratory. We assessed sample stability, inter- and intraassay var...
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CLINICAL CHEMISTRY, Vol. 26, No. 2, 1980 353 F.R.G.) of r = 0.95, as well as between the former method and a radioimmunoassay method (CIS-SORIN, Biomedica, 13040 Saluggia, Italy) of r = 0.92. The lackof correlation between serum ferritin and serum iron on one hand and the inverse relationship between serum ferritin and iron-binding capacity on the other, reported by Fortier et al. (1) and by Li...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2011
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2011.052852